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¡¡¡¡Financing Project Introduction
The technical reforming and constructing project of raw materials workshop belongs to one of the items of high-tech industry receiving the major supports of the state industry policy.One product of this project is the sole production of one of the national-class new organic selenium drugs, selenious yeast, and another one of the national Grade B new drugs as a substitutionproduct to replace the current NSAIDs with major GI side effects, nimesulide. Construction scale:annual productions of 20 tons of selenious yeast and 10 tons of nimesulide.

¡¡¡¡Total Investment and Capital Sources: Total investment of 90 million yuan among which the fixed asset investment is 70 million yuan and the flowing capital 20 million yuan, upon completion for production ,the annual sales revenue is 230 million yuan, tax 98 million yuan and profit 56 million Yuan.

¡¡¡¡The technical reforming and constructing project of new drug industrialization belongs to one of the items of high-tech industry receiving the major supports of the state industry policy. One product of this project is the Yang-revitalizing & Pulse-restoring Injection as one of the national Grade B new TCM drugs for emergency rescues.

¡¡¡¡Another one is the Zhishen Depression-busting Capsule (ZDC) as the national Grade B new TCM drugs. Construction Scale:Annual production of 50 million counts of ZDC and 50 million Yang-revitalizing & Pulse-restoring (YRPR) Injection.

¡¡¡¡Total Investment and Capital Sources: Total investment of 80 million yuan among which the fixed asset investment is 62 million yuan and the flowing capital 18 million yuan. Economic benefit: upon completion for production, the annual sales revenue is 250 million yuan, tax103 million yuan and profit 66 million yuan.

¡¡¡¡Financing Project Favorable Characteristics
¡¡¡¡1) Technical reforming and constructing project of new drug industrialization
¡¡¡¡ZDC: As one of Grade B new TCM drugs, it is the first Chinese product to treat depression by targeting the affected areas. At present, one Grade B new TCM antidepressant is lacking in China. And there are all sorts of side effects associated with the chemical drugs. The clinical practice is in urgent needs of some TCM antidepressants with definite efficacies and milder side effects. Almost all the western antidepressants have major side effects. Before the onset of effects, the patients must overcome the intolerable assaults of side effects so that they are always forced to discontinue the medication before the drugs become effective. The therapy is aborted mid-way. However, the development of ZDC has a high level of creativity. With a steady onset of effects, ZDC has almost no side effects for the patients.This demonstrates that TCM has such a prominent role in the therapeutic regimens for the psychiatric health, especially its unique advantages of treating depression.
¡¡¡¡YRPR Injection For a long time, the clinically common emergency resuscitation drug has been the epinephrine type injection. Though capable of raising a patient¡¯s blood pressure back to the normal level, the epinephrine injection is quite toxic and lasts for a stort period of time. With the effects of revitalizing Yang, invigorating primordial Qi (vital energy), strengthening body resistance, treating collapse, stimulating heart and elevating BP, YRPR is indicated for resuscitating the ER patients at Departments of Surgery, Medicine,Gynecology and Orthopedics,etc..During the course of resuscitative treatment for the acutely grave patients, YRPR has long-lasting and definite therapeutic effects. No toxic or side effects are found. It also has demonstrated unique effects upon the thrombus during the emergency rescue. YRPR injection is able to relieve somewhat such irregular cardiac events as angina pectoris. As one pure TCM preparation made from the effective ingredients of Radix Ginseng and Fructus Aurantii Immaturus, this product is produced by the modem techniques of extraction, isolation and purification. Not only retaining the characteristics of TCM theory, but also offering the edges of modern medicine and filling in the void of resuscitating TCM drugs.

¡¡¡¡2) Technical reforming and constructing project of raw materials workshop
¡¡¡¡Selenious Yeast Tablets As one of the essential trace elements of human body, selenium is one important component of glutathione peroxidase. Through boosting the activity of glutathione peroxidase, this drug has the pharmaceutical effects of removing the free radicals, accelerating the degradation of lipid peroxides, protecting the membrane integrity, strengthening the myocardial functions and enhancing the immunity so as to achieve the goals of preventing and treating diseases. Prepared by the biofermentative method, the yeast cells contain the inorganic selenium in organic forms so that its physiological activity is far greater than the inorganic selenium. The functions and parameters of this product are at the world leading level and the domestic void has been filled. The bioavailability ratio of this drug to the inorganic selenium is 3.45:1. It is listed as the one-and-only national new organic selenium drug. Through several years¡¯market development and clinical application, SFDA verfied the addition of new indications in 2002 and further established its roles in the treatment of liver diseases, cancers and cardiovascular diseases. The current manufacturing scale is no longer able to meet the market demands. This drug is mainly used to treat the cardiovascular diseases, liver diseases and cancers. With a marked efficacy, the clinical outcome is marked.

¡¡¡¡Nimesulide As one NSAID, antipyretic and pain-killer, it is mainly indicated for the treatment of rheumatoid arthritis. The efficacy is better than such existing categories as ibuprofen and naproxen. As one of the most representative category of the third generation NSAIDs,it is one leading national Grade B new drug among the same domestic class. As one high and new-tech product, nimesulide has the mechanistic feature of highly and selective inhibiting the pro-inflammatory cox-2 and protecting the normal physiologically functioning cox-1. As a result of this selective inhibition, it achieves its anti-inflammatory effects. At the same time, it has a minimal effect upon the intra-gastric synthesis of prostaglandins. The prostaglandins are capable of protecting the gastric mucous. Therefore,while showing the therapeutic effects,this drug has milder side effects.

 
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