¡¡¡¡Financing Project Introduction
The technical reforming and constructing project of raw materials
workshop belongs to one of the items of high-tech industry
receiving the major supports of the state industry policy.One
product of this project is the sole production of one of the
national-class new organic selenium drugs, selenious yeast,
and another one of the national Grade B new drugs as a substitutionproduct
to replace the current NSAIDs with major GI side effects,
nimesulide. Construction scale:annual productions of 20 tons
of selenious yeast and 10 tons of nimesulide.
¡¡¡¡Total Investment and Capital Sources: Total investment of
90 million yuan among which the fixed asset investment is
70 million yuan and the flowing capital 20 million yuan, upon
completion for production ,the annual sales revenue is 230
million yuan, tax 98 million yuan and profit 56 million Yuan.
¡¡¡¡The technical reforming and constructing project of new
drug industrialization belongs to one of the items of high-tech
industry receiving the major supports of the state industry
policy. One product of this project is the Yang-revitalizing
& Pulse-restoring Injection as one of the national Grade
B new TCM drugs for emergency rescues.
¡¡¡¡Another one is the Zhishen Depression-busting Capsule (ZDC)
as the national Grade B new TCM drugs. Construction Scale:Annual
production of 50 million counts of ZDC and 50 million Yang-revitalizing
& Pulse-restoring (YRPR) Injection.
¡¡¡¡Total Investment and Capital Sources: Total investment of
80 million yuan among which the fixed asset investment is
62 million yuan and the flowing capital 18 million yuan. Economic
benefit: upon completion for production, the annual sales
revenue is 250 million yuan, tax103 million yuan and profit
66 million yuan. ¡¡¡¡Financing Project Favorable Characteristics
¡¡¡¡1) Technical reforming and constructing project of new
drug industrialization
¡¡¡¡ZDC: As one of Grade B new TCM drugs, it is the first
Chinese product to treat depression by targeting the affected
areas. At present, one Grade B new TCM antidepressant is
lacking in China. And there are all sorts of side effects
associated with the chemical drugs. The clinical practice
is in urgent needs of some TCM antidepressants with definite
efficacies and milder side effects. Almost all the western
antidepressants have major side effects. Before the onset
of effects, the patients must overcome the intolerable assaults
of side effects so that they are always forced to discontinue
the medication before the drugs become effective. The therapy
is aborted mid-way. However, the development of ZDC has
a high level of creativity. With a steady onset of effects,
ZDC has almost no side effects for the patients.This demonstrates
that TCM has such a prominent role in the therapeutic regimens
for the psychiatric health, especially its unique advantages
of treating depression.
¡¡¡¡YRPR Injection For a long time, the clinically common
emergency resuscitation drug has been the epinephrine type
injection. Though capable of raising a patient¡¯s blood pressure
back to the normal level, the epinephrine injection is quite
toxic and lasts for a stort period of time. With the effects
of revitalizing Yang, invigorating primordial Qi (vital
energy), strengthening body resistance, treating collapse,
stimulating heart and elevating BP, YRPR is indicated for
resuscitating the ER patients at Departments of Surgery,
Medicine,Gynecology and Orthopedics,etc..During the course
of resuscitative treatment for the acutely grave patients,
YRPR has long-lasting and definite therapeutic effects.
No toxic or side effects are found. It also has demonstrated
unique effects upon the thrombus during the emergency rescue.
YRPR injection is able to relieve somewhat such irregular
cardiac events as angina pectoris. As one pure TCM preparation
made from the effective ingredients of Radix Ginseng and
Fructus Aurantii Immaturus, this product is produced by
the modem techniques of extraction, isolation and purification.
Not only retaining the characteristics of TCM theory, but
also offering the edges of modern medicine and filling in
the void of resuscitating TCM drugs.
¡¡¡¡2) Technical reforming and constructing project of raw
materials workshop
¡¡¡¡Selenious Yeast Tablets As one of the essential trace
elements of human body, selenium is one important component
of glutathione peroxidase. Through boosting the activity
of glutathione peroxidase, this drug has the pharmaceutical
effects of removing the free radicals, accelerating the
degradation of lipid peroxides, protecting the membrane
integrity, strengthening the myocardial functions and enhancing
the immunity so as to achieve the goals of preventing and
treating diseases. Prepared by the biofermentative method,
the yeast cells contain the inorganic selenium in organic
forms so that its physiological activity is far greater
than the inorganic selenium. The functions and parameters
of this product are at the world leading level and the domestic
void has been filled. The bioavailability ratio of this
drug to the inorganic selenium is 3.45:1. It is listed as
the one-and-only national new organic selenium drug. Through
several years¡¯market development and clinical application,
SFDA verfied the addition of new indications in 2002 and
further established its roles in the treatment of liver
diseases, cancers and cardiovascular diseases. The current
manufacturing scale is no longer able to meet the market
demands. This drug is mainly used to treat the cardiovascular
diseases, liver diseases and cancers. With a marked efficacy,
the clinical outcome is marked.
¡¡¡¡Nimesulide As one NSAID, antipyretic and pain-killer,
it is mainly indicated for the treatment of rheumatoid arthritis.
The efficacy is better than such existing categories as
ibuprofen and naproxen. As one of the most representative
category of the third generation NSAIDs,it is one leading
national Grade B new drug among the same domestic class.
As one high and new-tech product, nimesulide has the mechanistic
feature of highly and selective inhibiting the pro-inflammatory
cox-2 and protecting the normal physiologically functioning
cox-1. As a result of this selective inhibition, it achieves
its anti-inflammatory effects. At the same time, it has
a minimal effect upon the intra-gastric synthesis of prostaglandins.
The prostaglandins are capable of protecting the gastric
mucous. Therefore,while showing the therapeutic effects,this
drug has milder side effects.
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